- Roguebook
- Roller Champions
- Romance of the Three Kingdoms 13
- Romancing SaGa 3
- Rooftop Renegade
- Roots of Pacha
- Rory McIlroy PGA Tour
- Rough Justice: '84
- Roundabout
- Routine
- RPG Time: The Legend of Wright
- Ruff Ghanor
- Rugby 15
- Rugby 18
- Rugby 20
- Rugby 22
- Rugby Challenge 3
- Rugby League Live 3
- Rugby World Cup 2015
- Ruined King: A League of Legends Story
- Ruiner
- Rumbleverse
- Rune Factory 4
- Rust
- Rustler
- RWBY: Arrowfell
- RWBY: Grimm Eclipse
- Ryse: Son of Rome
- Ryse: Son of Rome - Duel of Fates
- Ryse: Son of Rome - Legendary Edition
- Ryse: Son of Rome - Mars' Chosen Pack
- Ryse: Son of Rome - Morituri Pack
- Sable
- Sail Forth
- Saint Kotar
- Saints Row: Gat Out of Hell
- Saints Row [II/2022]
- Saints Row: The Third Remastered
- Sam & Max Beyond Time and Space Remastered
- Sam & Max Save the World Remastered
- Samurai Jack: Battle Through Time
- Samurai Shodown 2
- Samurai Shodown 3: Blades of Blood
- Samurai Shodown 4: Amakusa's Revenge
- Samurai Shodown 5
- Samurai Shodown 5 Special
- Samurai Shodown [I/1993]
- Samurai Shodown [II/2019]
- Samurai Shodown NeoGeo Collection
- Samurai Warriors 5
- Sanity of Morris
- Saturnalia
- Save the Ninja Clan
- Sayonara Wild Hearts
- SBK 22
- Scalebound
- Scarf
- Scarlet Nexus
- Scars Above
- Scathe
- Scavengers
- Schrödinger's Cat and the Raiders of the Lost Quark
- Scott Pilgrim vs. the World: The Game
- ScourgeBringer
- ScreamRide
- Screencheat
- Scribblenauts Showdown
- SD Gundam Battle Alliance
- Sea of Solitude
- Sea of Stars
- Sea of Thieves
- Seasons After Fall
- Sébastien Loeb Rally Evo
- Second Extinction
- Secret Neighbor
- Sekiro: Shadows Die Twice
- Serial Cleaner
- Serial Cleaners
- Serious Sam 4
- Serious Sam Collection, The
- Session: Skate Sim
- Settlers: New Allies, The
- SEUM: Speedrunners from Hell
- Severed Steel
- Sexy Brutale, The
- Shadow Complex
- Shadow Man: Remastered
- Shadow of the Tomb Raider
- Shadow of the Tomb Raider: The Forge
- Shadow of the Tomb Raider: The Grand Caiman
- Shadow of the Tomb Raider: The Path Home
- Shadow of the Tomb Raider: The Pillar
- Shadow of the Tomb Raider: The Price of Survival
- Shadow of the Tomb Raider: The Serpent's Heart
- Shadow Tactics: Blades of the Shogun
- Shadow Warrior 2
- Shadow Warrior 3
- Shadow Warrior [II/2013]
- Shadowgate [II/2014]
- Shadowrun Trilogy