- Solar Swarm
- SolaRola
- SolForge
- Solitairica
- SongArc
- Sonic & All-Stars Racing Transformed
- Sonic at the Olympic Games Tokyo 2020
- Sonic CD
- Sonic Dash
- Sonic Dash 2: Sonic Boom
- Sonic Jump Fever
- Sonic Runners
- Sonic the Hedgehog 2 [II/1992]
- Sonic the Hedgehog 4: Episode 2
- Sonic the Hedgehog [I/1991]
- Sonic the Hedgehog 4: Episode 1
- Soul Seeker
- SoulCalibur
- SoulCraft 2: League of Angels
- South Park: Phone Destroyer
- Space Kitty Puzzle
- Space Noir
- Space Off
- Space Rangers: Legacy
- Space Rangers: Quest
- Space Shooter Blitz, A
- Space Spacy
- Spacecom
- Sparkle 2
- Sparkle 2: Evo
- Sparkle Epic
- Sparkle Unleashed
- Special Enquiry Detail: Engaged to Kill
- Spectral Souls: Resurrection of the Ethereal Empires
- Speedway GP 2012
- SpeedX 3D
- Spellcrafter
- Spellcreepers
- SpellForce: Heroes & Magic
- Spellspire
- Spider-Man Unlimited
- Spider: Rite of the Shrouded Moon
- Spine
- Spirit Lords
- Spiritfarer
- Splendor
- Splinter Cell: Blacklist - Spider-Bot
- SpongeBob SquarePants: Battle for Bikini Bottom - Rehydrated
- Spooklands
- Sports Car Challenge
- Sports Car Challenge 2
- Sproggiwood
- Squadron
- Squashies World
- Squirt's Adventure
- Stack
- Star Command
- Star Conflict Heroes
- Star Horizon
- Star Realms
- Star Skater
- Star Sky
- Star Vikings
- Star Warfare 2: Payback
- Star Wars: Assault Team
- Star Wars: Commander
- Star Wars: Force Collection
- Star Wars: Galactic Defense
- Star Wars: Galaxy of Heroes
- Star Wars: Hunters
- Star Wars: Knights of the Old Republic
- Star Wars: Knights of the Old Republic 2 - The Sith Lords
- Star Wars Rebels: Recon Missions
- Star Wars: Tiny Death Star
- Star Wars: Uprising
- Starborn Wanderers
- Stardew Valley
- Stars Wagon
- Starship Traveller
- Startup Panic
- Stay Alight
- Stealth Bastard Deluxe
- Steam Punks
- Steel Avengers
- Steel Commanders
- Steel Soldiers
- Steins;Gate
- Stellaris: Galaxy Command
- Steve Jackson’s Sorcery!
- Steve Jackson’s Sorcery! Part 2
- Steve Jackson’s Sorcery! Part 3
- Steve Jackson’s Sorcery! Part 4: The Crown of Kings
- Stick Cricket 2
- Storm Age
- Stormblades
- Story of a Gladiator
- Stranded: A Mars Adventure
- Stranger Things: The Game
- Strata
- Strategy & Tactics: World War II