- Sonic Colors
- Sonic and the Black Knight
- Sonic & SEGA All-Stars Racing
- Sonic & Knuckles
- Soccer Up!
- Soccer Bashi
- So Blonde: Back to the Island
- Sniper Elite
- Smurfs Dance Party, The
- Smurfs 2, The
- Sled Shred
- Skylanders Trap Team
- Skylanders: SWAP Force
- Skylanders: SuperChargers
- Skylanders: Spyro's Adventure
- Skylanders: Giants
- Sky Crawlers: Innocent Aces, The
- Ski Doo: Snowmobile Challenge
- Skate It
- Sin and Punishment: Star Successor
- Sims 3, The
- SimCity [I/1989]
- SimAnimals Africa
- SimAnimals
- Silent Hill: Shattered Memories
- Sid Meier's Pirates! [II/2004]
- Shrek's Carnival Craze
- Shrek Forever After: The Game
- Shootanto: Evolutionary Mayhem
- Shiren the Wanderer
- Shin Megami Tensei
- Shimano Xtreme Fishing
- Shaun White Snowboarding: World Stage
- Shaun White Skateboarding
- Shakedown: Hawaii
- Sesame Street: Ready, Set, Grover!
- Sesame Street: Elmo's Musical Monsterpiece
- Sesame Street: Elmo's A-to-Zoo Adventure
- Sesame Street: Cookie's Counting Carnival
- Sengoku Basara: Samurai Heroes
- Sega Superstars Tennis
- Secret Saturdays: Beasts of the 5th Sun, The
- Secret of Mana [I/1993]
- Secret Files: Tunguska
- Secret Files 2: Puritas Cordis
- Scrabble Interactive: 2009 Edition
- Score International Baja 1000
- Scooby-Doo! First Frights
- Scooby-Doo! and the Spooky Swamp
- Scene It? Twilight
- Scarface: The World Is Yours
- Save the Furries!
- Samurai Warriors 3
- Samurai Shodown [I/1993]
- Samurai Shodown 4: Amakusa's Revenge
- Samurai Shodown 3: Blades of Blood
- Samurai Shodown 2
- Sam & Max Season 2
- Sakura Wars: So Long, My Love
- Saddle Club, The
- Saban's Power Rangers: Samurai
- Rush Rush Rally Racing
- Rune Factory: Tides of Destiny
- Rune Factory: Frontier
- Runaway 2: The Dream of the Turtle
- Rugby League 3
- Rubik's Puzzle Galaxy: Rush
- RTL Winter Sports 2010: The Great Tournament
- Rooms: The Main Building
- Roogoo
- Romancing SaGa 3
- Romancing SaGa 2
- Rogue Trooper: Quartz Zone Massacre
- Rodea the Sky Soldier
- Rock Band 3
- Rock Band 2
- Robox
- Robocalypse: Beaver Defense
- Rise of the Guardians: The Video Game
- Rio: The Multiplayer Party Game
- Ringling Bros. and Barnum & Bailey
- Rhythm Heaven Fever
- Retro City Rampage
- Resident Evil Zero
- Resident Evil: The Umbrella Chronicles
- Resident Evil: The Darkside Chronicles
- Resident Evil [II/2002]
- Resident Evil 4 [I/2005]
- Remington Super Slam Hunting: North America
- Remington Super Slam Hunting: Africa
- Remington Great American Bird Hunt
- Reload
- Reel Fishing: Ocean Challenge
- Reel Fishing Challenge
- Reel Fishing: Angler's Dream
- Red Steel 2
- Rec Room Games
- Real Madrid: The Game
- Real Heroes: Firefighter
- Ready 2 Rumble Revolution