- Smart as...
- Söldner-X 2: Final Prototype
- Sonic & All-Stars Racing Transformed
- Sorcery Saga: The Curse of the Great Curry God
- Soul Sacrifice
- Soul Sacrifice Delta
- Sound Shapes
- Space Hulk: Ascension
- Space Overlords
- Sparkle 2
- Sparkle Unleashed
- Spellspire
- Spelunky [II/2012]
- Spheroids
- Spider: Rite of the Shrouded Moon
- SpongeBob HeroPants
- Spy Chameleon: RGB Agent
- Spy Hunter [II/2012]
- Squares
- Star Ocean: The Second Story
- Star Wars Pinball
- Stardew Valley
- StarDrone
- Starlight Inception
- Stealth Bastard Deluxe
- Stealth Inc. 2: A Game of Clones
- Stealth Inc.: The Lost Clones
- SteamWorld Dig
- SteamWorld Dig 2
- SteamWorld Heist
- Steins;Gate
- Steins;Gate 0
- Steins;Gate Elite
- Steins;Gate: Linear Bounded Phenogram
- Steins;Gate: My Darling's Embrace
- Stick It to the Man!
- Still Time
- Stranded: A Mars Adventure
- Stranger of Sword City
- Street Fighter x Tekken
- Strikers 1945 2
- Suikoden 2
- Sumioni: Demon Arts
- Summon Night 6: Lost Borders
- SunFlowers
- Super Crate Box
- Super Exploding Zoo
- Super Hydorah
- Super Meat Boy
- Super Monkey Ball: Banana Splitz
- Super Robot Wars V
- Super Robot Wars X
- Super Star Wars
- Super Stardust Delta
- Super Time Force
- Superbeat: Xonic
- Superdimension Neptune vs Sega Hard Girls
- Superfrog HD
- Supremacy MMA
- Swapper, The
- Swindle, The
- Switch Galaxy Ultra
- Sword Art Online: Hollow Fragment
- Sword Art Online: Hollow Realization
- Sword Art Online: Lost Song
- Syphon Filter
- Syphon Filter 3
- Table Ice Hockey
- Table Soccer
- Table Top Racing
- Table Top Tanks
- Taco Master
- Tales from Space: Mutant Blobs Attack!
- Tales of Hearts R
- Tales of Innocence R
- Tearaway
- Tennis in the Face
- Terraria
- Teslagrad
- Tetris Ultimate
- Thomas Was Alone
- Three Fourths Home: Extended Edition
- Time Travelers
- Timespinner
- Tiny Troopers: Joint Ops
- Tipper
- Titan Attacks!
- Titan Souls
- To Leave
- Tokyo Jungle Mobile
- Tokyo Tattoo Girls
- Tokyo Twilight: Ghost Hunters
- Tokyo Xanadu
- Tomb Raider Chronicles
- Tomb Raider [I/1996]
- Top Darts
- Touch My Katamari
- Touhou Genso Wanderer
- Touhou Kobuto V: Burst Battle
- Touhou Sky Arena: Matsuri Climax